Secular Trends on Birth Parameters, Growth, and Pubertal Timing in Girls with Turner Syndrome.

BACKGROUND: Whether children with chromosomal disorders of growth and puberty are affected by secular trends (STs) as observed in the general population remains unanswered, but this question has relevance for expectations of spontaneous development and treatment responses. OBJECTIVES: The aim of the study was to evaluate STs in birth parameters, growth, and pubertal development in girls with Turner syndrome (TS). STUDY DESIGN: Retrospective analysis of KIGS data (Pfizer International Growth Database). We included all TS patients who entered KIGS between 1987 and 2012 and were born from 1975 to 2004, who were prepubertal and growth treatment naïve at first entry (total number: 7,219). Pretreatment height and ages at the start of treatment were compared across 5-year birth year groups, with subgroup analyses stratified by induced or spontaneous puberty start. RESULTS: We observed significant STs across the birth year groups for birth weight [+0.18 SD score (SDS), p < 0.001], pretreatment height at mean age 8 years (+0.73 SDS, p < 0.001), height at the start of growth hormone (GH) therapy (+0.38 SDS, p < 0.001) and start of puberty (+0.42 SDS, p < 0.001). Spontaneous puberty onset increased from 15 to 30% (p < 0.001). Mean age at the start of GH treatment decreased from 10.8 to 7.4 years (-3.4 years; p < 0.001), and substantial declines were seen in ages at onset of spontaneous and induced puberty (-2.0 years; p < 0.001) and menarche (-2.1 years; p < 0.001). CONCLUSION: Environmental changes leading to increased height and earlier and also more common, spontaneous puberty are applicable in TS as in normal girls. In addition, greater awareness for TS may underlie trends to earlier start of GH therapy and induction of puberty at a more physiological age

Mindful Self-Care Scale (MSCS): Adaptation and Validation in a Normative Turkish Sample

The aim of this study was to adapt and validate Mindful Self-Care Scale (MSCS) with a normative Turkish sample. Participants of the study were 330 university students (232 females and 97 males) along with the age mean of 20.22 (SD=1.32). In order to validate the six factor structure of Mindful Self-care Scale, a confirmatory factor analysis was conducted. For providing evidence over convergent validity, Mindful Attention Awareness Scale-Adolescent version (Brown, West, Loverich &amp; Biegel, 2011) was concurrently used. The results of the confirmatory factor analysis&nbsp; displayed satisfactory evidence for the six factor Mindful Self-Care Scale (&chi;2 / df = 1.7; GFI = 0.87, CFI = 0.92; TLI = .91; RMSEA = 0.05). The scale was also found to be significantly correlated to Mindful Attention Awareness Scale-Adolescent (r=.27, p&lt;.001). Also, the Cronbach Alpha value for the whole scale was found .89 yielding satisfactory evidence for the internal consistency of the instrument. The results of the study tentatively yielded that the Mindful Self-Care Scale is a valid and reliable assessment tool of self-care in Turkish culture. As well, further studies examining the psychometric properties of Mindful Self-Care Scale are still needed with larger and diverse samples

Response to GH Treatment After Radiation Therapy Depends on Location of Irradiation

OBJECTIVES: Cancer survivors with GH deficiency (GHD) receive GH therapy (GHT) after 1+ year observation to ensure stable tumor status/resolution. HYPOTHESIS: Radiation therapy (RT) to brain, spine, or extremities alters growth response to GHT. AIM: Identify differences in growth response to GHT according to type/location of RT. METHODS: The Pfizer International Growth Database was searched for cancer survivors on GHT for ≥5 years. Patient data, grouped by tumor type, were analyzed for therapy (surgery, chemotherapy, RT of the focal central nervous system, cranial, craniospinal, or total body irradiation [TBI] as part of bone marrow transplantation), sex, peak stimulated GH, age at GHT start, and duration from RT to GHT start. Kruskal-Wallis test and quantile regression modeling were performed. RESULTS: Of 1149 GHD survivors on GHT for ≥5 years (male 733; median age 8.4 years; GH peak 2.8 ng/mL), 431 had craniopharyngioma (251, cranial RT), 224 medulloblastoma (craniospinal RT), 134 leukemia (72 TBI), and 360 other tumors. Median age differed by tumor group (P < 0.001). Five-year delta height SD score (SDS) (5-year ∆HtSDS; median [10th-90th percentile]) was greatest for craniopharyngioma, 1.6 (0.3-3.0); for medulloblastoma, 5-year ∆HtSDS 0.9 (0.0-1.9); for leukemia 5-year ∆HtSDS, after TBI (0.3, 0-0.7) versus without RT (0.5, 0-0.9), direct comparison P < 0.001. Adverse events included 40 treatment-related, but none unexpected. CONCLUSIONS: TBI for leukemia had significant impact on growth response to GHT. Medulloblastoma survivors had intermediate GHT response, whereas craniopharyngioma cranial RT did not alter GHT response. Both craniospinal and epiphyseal irradiation negatively affect growth response to GH therapy compared with only cranial RT or no RT

Checklist of Bryozoa on the coasts of Turkey

The phylum Bryozoa includes a total of 185 species reported from the Turkish coasts of the Levantine Sea, the Aegean Sea, the Sea of Marmara, and the Black Sea. The class Gymnolaemata is represented by 159 species, followed by the class Stenolaemata (26 species). While the Aegean Sea had the highest species richness (139 species), the lowest bryozoan diversity (8 species) was reported from the Black Sea coast of Turkey. Only 2 alien species, Celleporaria brunnea and Rhynchozoon larreyi, were recorded from the Turkish coasts

Evaluation of spatial and temporal variations of inorganic nutrient species in the eastern Aegean Sea waters

In this study, the state of the five stations' quality was assessed on the basis of determination of temporal and spatial variability of nutrients with physicochemical variables. Besides this, organic matter of sediment, secchi disc depth and suspended solids were also determined. The samples were collected seasonally from different areas such as harbor and important touristic marinas along the eastern Aegean during June 2008-2009. As a result, the nutrients ranged between NH4: 0.10-25.6, NO2: 0.01-1.5, NO3: 0.19-7.0, o.PO4: 0.17-6.8, TPO4: 0.32-9.6 and Si: 030-13.8 mu M, respectively. Precipitation leads to large changes in temperature, salinity, dissolved oxygen and nutrients. The highest nutrient values in this study were observed during the rainy season except o.PO4-P and TPO4-P. However, the physico-chemical variables have exhibited considerable temporal variations while nutrients showed spatial differences. The relatively high nutrient increase in the sampling stations coupled with surface runoff events during rainy period and pollution arising from both point and non-point sources. (C) 2012 Elsevier Ltd. All rights reserved

Assessment of heavy metal contamination in Hediste diversicolor (OF Muller, 1776), Mugil cephalus (Linnaeus, 1758), and surface sediments of Bafa Lake (Eastern Aegean)

In the present study, the bioaccumulation of six heavy metals (Cd, Cr, Cu, Hg, Pb, and Zn) in Hediste (Nereis) diversicolor (O.F. Muller, 1776) and also in the muscle and liver of Mugil cephalus (Linnaeus, 1758) collected from seven stations in the Bafa Lake was investigated. Sediment samples were also collected in each site to assess heavy metal levels and to provide additional information on pollution of the lake. The mean concentrations of heavy metals in sediment, H. diversicolor, and muscle and liver of the fish were found to be in the magnitude of Cr > Pb > Zn > Cu > Cd > Hg, Zn > Cu > Cr > Pb > Hg > Cd, Zn > Cu > Pb > Cr > Hg > Cd, and Cu > Zn > Cr > Cd > Pb > Hg, respectively. Hg, Cu, and Zn in H. diversicolor and Hg and Zn in muscle and also Hg, Cd, Cu, and Zn in liver of fish accumulated in a higher degree than in sediment. There was no clear relationship between metal concentrations in sediments, polychaetes, and fish, except Cr. According to international criteria and Turkish regulations, Pb and Zn values in edible muscle of the fish collected from stations S6 and S5 exceeded the food safety limits, respectively. The results of this study suggest that these sentinel species can be considered as good anthropogenic biological indicators for heavy metal pollution along the Bafa Lake

The interaction between breathing and swallowing in healthy individuals

WOS: 000318905600019PubMed ID: 23261084In this article, we aimed at investigating the interaction between breathing and swallowing patterns in normal subjects. Ten healthy volunteers were included in the study. Diaphragm EMG activity was recorded by a needle electrode inserted into the 7th or 8th intercostal space. Swallowing was monitored by submental EMG activity, and laryngeal vertical movement was recorded by using a movement sensor. A single voluntary swallow was initiated during either the inspiration or expiration phases of respiration, and changes in EMG activity were evaluated. When a swallow coincided with either inspiration or expiration, the duration of the respiratory phase was prolonged. Normal subjects were able to voluntarily swallow during inspiration. During the inspiration phase with swallowing, diaphragmatic activity did not ceased and during the expiration phase with swallowing, there was a muscle activity in the diaphragm muscle. (C) 2012 Elsevier Ltd. All rights reserved